Byron Loomis was the son of Neland Loomis, one of the six Loomis brothers who established themselves in Suffield as tobacco merchants (another brother was John Welles Loomis). Byron Loomis, who became one of the wealthiest tobacco barons in Suffield, may have built his Italianate house on South Main Street as early as 1850, or perhaps in the 1860s.