Captain Job Camp built a house on Main Street in Durham in the eighteenth century, which later passed to his son, Manoah Camp and then to his grandson, Elizur Camp, both of whom were shoemakers. In 1861, this original house was given by Elizur Camp to his daughter, Susan E. Camp, who had married Francis Hubbard in 1857. They replaced the old house with a new one in 1862. Francis Hubbard was an owner of the Merriam Manufacturing Company. The house remained in the Hubbard family until it was sold to Frederick Brewster, a wealthy New Haven businessman who owned Brookfield Farm in Durham. Concerned about the fact that Durham did not have a resident physician, he rented the house to a series of doctors from 1928 to 1941.

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Francis Hubbard House (1862)