The Colonial Revival house at 110 South Street in Bristol was built c. 1909 by local builder George J. LaCourse (1880-1941). He first moved an earlier house from the site, that had been built about a century before by Thomas Barns, Jr. That house was later occupied by Barns’ grandson, Thomas Barnes (who added an e to the family name). LaCourse, who is credited with having built 250 residences in Bristol (both single-family and multi-family), later built a new house for his own family at 57 George Street. In 1918, the influenza epidemic spurred plans to start a hospital in Bristol. The Wallace Barnes Company, which owned the house at the time, sold it to the Hospital Association to use as a temporary home until a new hospital complex was built. In December 1921 the house opened in its new role with space for 22 patients and quarters for nurses. When the new hospital opened the house was converted into a multi-family dewelling.